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Mrm2741-SupInfo.docxapplication/docx, 815 KBįIGURE S1 The comparison of the image phase from diffusion encoding and eddy-current, using the DTI data set at b = 1000 s/mm 2 (Table 1, scan 4). Whole-brain T 2-weighted, T 2 *-weighted, and diffusion imaging can be obtained in just 15–60 s. Tilted-CAIPI achieved fast distortion- and blurring-free imaging with high SNR. The ability of tilted-CAIPI to provide highly accelerated imaging without distortion and blurring was demonstrated through in vivo brain experiments, where only 8 shots per simultaneous slice group were required to provide high-quality, high-SNR imaging at 0.8–1 mm resolution. T 2-weighted, T 2 *-weighted, and diffusion-weighted imaging experiments were conducted to evaluate the proposed method. Tilted-CAIPI was implemented at 3T, with incorporation of partial Fourier and simultaneous multislice to achieve further accelerations. Self-navigated phase correction was developed to correct shot-to-shot phase variation in diffusion imaging. Susceptibility-induced phase accumulation is regarded as an additional encoding that is estimated by calibration data and integrated into reconstruction. The proposed method systematically optimized the k-space sampling trajectory with B 0-inhomogeneity-informed reconstruction, to exploit the inherent signal correlation in PSF-EPI and take full advantage of coil sensitivity. In this study, an acquisition/reconstruction technique, termed “tilted-CAIPI,” is proposed to achieve >20× acceleration for PSF-EPI. Theory: EPI with point-spread-function (PSF) mapping can achieve distortion- and blurring-free imaging at a cost of long acquisition time. To develop a method for fast distortion- and blurring-free imaging.
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